Adenocarcinoma

Invasive adenocarcinomas should be subclassified into the endocervical or endometrial type whenever possible. The cytological diagnosis of invasive adenocarcinoma is relatively straightforward.

Adenocarcinoma cells from either an endocervical or an endometrial primary type have enlarged nuclei, high nuclear: cytoplasmic ratios, coarsely clumped chromatin and prominent nucleoli (Figure 41). They can occur singly or in clusters.