Although the 2001 Bethesda System classification is applied in many countries, other classification systems are also widely used. As mentioned previously, many countries prefer to subclassify high-grade intraepithelial lesions into at least two categories. This is the approach used in the United Kingdom, where squamous intraepithelial abnormalities are divided into five categories (borderline changes; mild, moderate, severe dyskaryosis and severe dyskaryosis or possibly invasive cancer) (British Society for Clinical Cytology, 1997)
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